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Course: Review of IL-13 in Atopic Dermatitis Pathogenesis and the Biologics that Target This Cytokine
Atopic Dermatitis Pathogenesis and the Biologics that Target This Cytokine
Raja Sivamani, MD MS AP +1
Supported by LEO Pharma

This lecture will review the immunology and the inflammatory pathophysiology of atopic dermatitis, including the role of cytokine signaling and the JAK pathway. The clinical evidence, the evidence for tapering regimens, and the safety for the use of emerging therapies will be discussed.

Learning Objectives:

  • Diagram the role of IL-4, IL-13, and the JAK pathway in the pathogenesis of atopic dermatitis
  • Summarize the clinical evidence for the use of systemic therapies and the evidence for the use of tapering regimens
  • Describe and compare the safety issues related to the use of systemic therapies, especially among emerging IL-13 and JAK inhibitors

Supported by LEO Pharma Inc.

Faculty

User: Raja Sivamani
Raja Sivamani
MD MS AP

Dr. Raja Sivamani is a board-certified dermatologist and practices as an integrative dermatologist at Pacific Skin Institute. He is an Adjunct Associate Professor of Clinical Dermatology at the University of California, Davis and Director of Clinical Research and the Clinical Trials Unit.He is also an Adjunct Assistant Professor in the Department of Biological Sciences at the California State University, Sacramento and an Associate Professor of Dermatology at California Northstate University, College of Medicine.He engages in clinical practice as well as both clinical and translational research that integrates bioengineering, nutrition, cosmetics, and skin biology. With training in both Allopathic and Ayurvedic medicine, he takes an integrative approach to his patients and in his research.He has published over 100 peer-reviewed research manuscripts, 10 textbook chapters, and a textbook entitled Cosmeceuticals and Active Cosmetics, 3rd Edition with a passion for expanding the evidence and boundaries of integrative medicine for skin care.

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Tina Bhutani-Jacques
Tina Bhutani
MD MAS

Dr. Tina Bhutani is a board certified dermatologist and clinical researcher practicing in San Francisco, California. She received her medical training at the University of Southern California Keck School of Medicine and completed her residency in dermatology at UCSF. Dr. Bhutani has an expertise in the treatment of psoriasis, atopic dermatitis, and other inflammatory skin diseases. In addition to seeing patients, she is a Associate Adjunct Professor in the Department of Dermatology at UCSF. She is passionate about improving the care and lives of patients with inflammatory skin disorders and is involved in many studies focusing on the development of new treatments for these diseases and learning more about mechanisms of disease initiation and maintenance. She has a particular interest in the impact of disease on patient quality of life and mental health as well as the use of wellness-based behavior modification to improve disease severity and reduce the risk of associated comorbidities. She has published over 150 articles in peer-reviewed journals and has spoken at national and international conferences on these topics. She is a member of the National Psoriasis Foundation (NPF) Scientific Advisory committee and has received research grant funding from the NPF, the Dermatology Foundation, as well as Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). She also serves as the current editor-in-chief for the journal Psoriasis: Targets and Therapy. 

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